A 67-year-old man was driving his car down the expressway when he noticed that his hands were swollen, red, and extremely itchy. The patient was having difficulty breathing, swallowing, and talking, and his tongue was swollen. He pulled over at a rest stop, got out of his car, found 2 men working at the rest stop building, and asked for help. The patient was experiencing extreme itching and shaking. The 2 men sat him in a chair and called 911. The patient appeared to be very confused, and, as the paramedics arrived, the patient had a sudden loss of consciousness.