Abstract
Kratom ingestion for its psychotropic effect or to self-treat opioid withdrawal symptoms
has increased over the last 10 years in the United States. Although mild adverse effects
have been observed in users, reports of respiratory failure and shock after kratom
consumption remain rare. In this case, a 35-year-old man initially presented to the
emergency department with profound circulatory shock, metabolic acidosis, hypoxia,
and symptoms of autonomic nervous system dysfunction. The patient required vasopressor
support, multiregimen sedation and rapid sequence intubation, mechanical ventilation,
and emergent hemodialysis. Within 72 hours, the patient’s condition stabilized, and
he was extubated. The patient reported regular consumption of large quantities of
kratom as well as injection of heroin and cocaine. In this report, a rare clinical
presentation after kratom ingestion is described.
Key words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Emergency NursingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Death from Kratom toxicity and the possible role of intralipid.J Intensive Care Soc. 2018; 19: 61-63https://doi.org/10.1177/1751143717712652
- Kratom, an emerging drug of abuse, raises prolactin and causes secondary hypogonadism: case report.J Investig Med High Impact Case Rep. 2018; 6 (2324709618765022. https://doi.org/10.1177/2324709618765022)
- Pharmacologic and clinical assessment of kratom.Am J Health Syst Pharm. 2018; 75: 261-267https://doi.org/10.2146/ajhp161035
- Introducing... Kratom. J Emerg Nurs. 2017; 43: 373-374https://doi.org/10.1016/j.jen.2017.03.016
- Kratom policy: the challenge of balancing therapeutic potential with public safety.Int J Drug Policy. 2019; 70: 70-77https://doi.org/10.1016/j.drugpo.2019.05.003
- Current perspectives on the impact of Kratom use.Subst Abuse Rehabil. 2019; 10: 23-31https://doi.org/10.2147/SAR.S164261
- Legally lethal kratom: a herbal supplement with overdose potential.J Psychoactive Drugs. 2019; 51: 28-30https://doi.org/10.1080/02791072.2018.1562591
- Kratom from head to toe—case reviews of adverse events and toxicities.Curr Emerg Hosp Med Rep. 2019; 7: 144-168https://doi.org/10.1007/s40138-019-00194-1
- Kratom exposures reported to United States poison control centers: 2011-2017.Clin Toxicol. 2019; 57: 847-854https://doi.org/10.1080/15563650.2019.1569236
- Emergency neurological life support: airway, ventilation, and sedation.Neurocrit Care. 2012; 17: S4-S20https://doi.org/10.1007/s12028-012-9753-6
- Seizure and coma following Kratom (Mitragynina speciosa Korth) exposure.J Med Toxicol. 2010; 6: 424-426https://doi.org/10.1007/s13181-010-0079-5
- A study of kratom eaters in Thailand.Bull Narc. 1975; 27 (https://pubmed.ncbi.nlm.nih.gov/1041694/): 21-27
- Fatal mitragynine-associated toxicity in Canada: a case report and review of the literature.Acad Forensic Pathol. 2018; 8: 340-346https://doi.org/10.1177/1925362118782076
- Kratom use and mental health: a systematic review.Drug Alcohol Depend. 2018; 183: 134-140https://doi.org/10.1016/j.drugalcdep.2017.10.012
- Notes from the field: unintentional drug overdose deaths with kratom detected - 27 states, July 2016-December 2017.MMWR Morb Mortal Wkly Rep. 2019; 68: 326-327https://doi.org/10.15585/mmwr.mm6814a2
- Pharmacokinetics of mitragynine in man.Drug Des Devel Ther. 2015; 9: 2421-2429https://doi.org/10.2147/DDDT.S79658
- The neuromuscular blockade produced by pure alkaloid, mitragynine and methanol extract of kratom leaves (Mitragyna speciosa Korth).J Ethnopharmacol. 2010; 129: 344-349https://doi.org/10.1016/j.jep.2010.03.035
- Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa Korth).Addiction. 2008; 103: 1048-1050https://doi.org/10.1111/j.1360-0443.2008.02209.x
- Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems.Eur J Pharmacol. 1996; 317: 75-81https://doi.org/10.1016/s0014-2999(96)00714-5
- Exploration of cytochrome P450 inhibition mediated drug–drug interaction potential of kratom alkaloids.Toxicol Lett. 2020; 319: 148-154https://doi.org/10.1016/j.toxlet.2019.11.005
- From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction.Neurosci Biobehav Rev. 2013; 37: 138-151https://doi.org/10.1016/j.neubiorev.2012.11.012
- Kratom (mitragynine) ingestion requiring naloxone reversal.Clin Pract Cases Emerg Med. 2019; 3: 24-26https://doi.org/10.5811/cpcem.2018.11.40588
- Toxidromes. Crit Care Clin. 2012; 28: 479-498https://doi.org/10.1016/j.ccc.2012.07.008
- Complications from administration of vasopressors through peripheral venous catheters: an observational study.J Emerg Med. 2018; 54: 47-53https://doi.org/10.1016/j.jemermed.2017.09.007
- Safety of peripheral administration of vasopressor medications: a systematic review.Emerg Med Australas. 2020; 32: 220-227https://doi.org/10.1111/1742-6723.13406
- Complication of vasopressor infusion through peripheral venous catheter: a systematic review and meta-analysis.Am J Emerg Med. 2020; 38: 2434-2443https://doi.org/10.1016/j.ajem.2020.09.047
- Neuroleptic malignant syndrome: a review from a clinically oriented perspective.Curr Neuropharmacol. 2015; 13: 395-406https://doi.org/10.2174/1570159x13999150424113345
- Care of the patient in excited delirium.J Emerg Nurs. 2013; 39: 190-196https://doi.org/10.1016/j.jen.2012.03.007
- Pharmacological aspects and potential new clinical applications of ketamine: reevaluation of an old drug.J Clin Pharmacol. 2009; 49: 957-964https://doi.org/10.1177/0091270009337941
- Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update.Ann Emerg Med. 2011; 57: 449-461https://doi.org/10.1016/j.annemergmed.2010.11.030
- Cardiac arrest in a young healthy male patient secondary to kratom ingestion: is this ‘legal high’ substance more dangerous than initially thought?.BMJ Case Rep. 2019; 12e229778https://doi.org/10.1136/bcr-2019-229778
Biography
Alex Hall is Director of Clinical Trials, Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA.
Biography
Dora Hall is Clinical Pharamcy Specialist, Emergency Medicine, Department of Pharmaceutical Services, Emory Decatur Hospital, Decatur, GA.
Article info
Publication history
Published online: April 13, 2021
Footnotes
Earn Up to 12.0 Hours. See page 675.
Submissions to this column are encouraged and may be submitted at jenonline.org where submission instructions can be found in the Author Instructions.
Identification
Copyright
© 2021 Emergency Nurses Association. Published by Elsevier Inc. All rights reserved.