Journal of Emergency Nursing
Volume 33, Issue 4 , Pages 342-345 , August 2007

Ethylene Glycol Poisoning: Current Diagnostic and Management Issues

  • Larissa I. Velez, MD, FACEP
    • ,
  • Rebeca Gracia, PharmD, DABAT
    • ,
  • Michael F. Neerman, PhD

      Affiliations

    • Corresponding Author InformationFor correspondence, write: Michael F. Neerman, PhD, North Texas Poison Center, Parkland Health & Hospital System, 5201 Harry Hines Blvd. Dallas, TX 75235

References 

  1. Barceloux DG, Krenzelok EP, Olson K, Watson W. American Academy of Clinical Toxicology practice guidelines on the treatment of ethylene glycol poisoning. Ad Hoc Committee. J Toxicol Clin Toxicol. 1999;37:537–560
  2. Davis DP, Bramwell KJ, Hamilton RS, Williams SR. Ethylene glycol poisoning: case report of a record-high level and a review. J Emerg Med. 1997;15:653–667
  3. Gordon HL, Hunter JM. Ethylene glycol poisoning. A case report. Anaesthesia. 1982;37:332–338
  4. Flanagan P, Libcke JH. Renal biopsy observations following recovery from ethylene glycol nephrosis. Am J Clin Pathol. 1964;41:171–175
  5. Wallace KL, Suchard JR, Curry SC, Reagan C. Diagnostic use of physicians' detection of urine fluorescence in a simulated ingestion of sodium fluorescein-containing antifreeze. Ann Emerg Med. 2001;38:49–54
  6. Chyka PA, Seger D. Position statement: single-dose activated charcoal. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. J Toxicol Clin Toxicol. 1997;35:721–741
  7. Vale JA. Position statement: gastric lavage. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. J Toxicol Clin Toxicol. 1997;35:711–719
  8. Wacker WE, Haynes H, Druyan R, Fisher W, Coleman JE. Treatment of ethylene glycol poisoning with ethyl alcohol. JAMA. 1965;194:1231–1233
  9. Pietruszko R, Voigtlander K, Lester D. Alcohol dehydrogenase from human and horse liver—substrate specificity with diols. Biochem Pharmacol. 1978;27:1296–1297
  10. Burns MJ, Graudins A, Aaron CK, McMartin K, Brent J. Treatment of methanol poisoning with intravenous 4-methypyrazole. Ann Emerg Med. 1997;30:829–832
  11. Jobard E, Harry P, Turcant A, Roy PM, Allain P. 4-Methyl pyrazole and hemodialysis in ethylene glycol poisoning. J Toxicol Clin Toxicol. 1996;34:373–377
  12. Antizol (fomepizole). Package insert. Minnetonka, MN: Orphan Medical; December 2000.
  13. Velez LI, Kulstad E, Shepherd G, Roth B. Inhalational methanol toxicity in pregnancy treated twice with fomepizole. Vet Hum Toxicol. 2003;45:28–30
  14. Curtin L, Kraner J, Wine H, Savitt D, Abuelo JG. Complete recovery after massive ethylene glycol ingestion. Arch Intern Med. 1992;152:1311–1313
  15. Sivilotti ML, Burns MJ, McMartin KE, Brent J. Toxicokinetics of ethylene glycol during fomepizole therapy: implications for management. For the Methylpyrazole for Toxic Alcohols Study Group. Ann Emerg Med. 2000;36:114–125

 Earn Up to 8 CE Hours. See page 414.

PII: S0099-1767(06)00799-9

doi: 10.1016/j.jen.2006.12.019

Journal of Emergency Nursing
Volume 33, Issue 4 , Pages 342-345 , August 2007

Article Tools