Journal of Emergency Nursing
Volume 32, Issue 4, Supplement , Pages S12-S18 , August 2006

Recognition and Treatment of Acute Cyanide Poisoning

  • Stephen W. Borron, MD, MS

      Affiliations

    • Corresponding Author InformationFor correspondence, write: Stephen W. Borron, MD, MS, FACEP, FACMT, Division of Emergency Medicine (Surgery), MSC 7736, 7703 Floyd Curl Drive, San Antonio, TX 78229

References 

  1. Peddy SB, Rigby MR, Shaffner DH. Acute cyanide poisoning. Pediatr Crit Care Med. 2006;7:79–82
  2. Dart RC, Bogdan GM. Acute cyanide poisoning: causes, consequences, recognition and management. Frontline First Responder. 2004;2:19–22
  3. Gracia R, Shepherd G. Cyanide poisoning and its treatment. Pharmacotherapy. 2004;24:1358–1365
  4. Morocco AP. Cyanides. Crit Care Clin. 2005;21:691–705
  5. Schnepp JR. Sources of human exposure to cyanide. J Emerg Med. 2006;32(suppl):S3–S7
  6. Walsh DW, Eckstein M. Hydrogen cyanide in fire smoke: an under appreciated threat. Emerg Med Serv. 2004;33:160–163
  7. Alarie Y. Toxicity of fire smoke. Crit Rev Toxicol. 2002;32:259–289
  8. Augustine JJ. Smoke and fire: recognizing cyanide as a toxic agent. fireEMS. 2005;May:18–23
  9. Baud F, Barriot P, Toffis V, et al. Elevated blood cyanide concentrations in victims of smoke inhalation. N Engl J Med. 1991;325:1761–1766
  10. Megarbane B, Delahaye A, Goldgran-Toledano D, Baud FJ. Antidotal treatment of cyanide poisoning. J Chin Med Assoc. 2003;66:193–203
  11. Gracia R. Cyanide. In:  Keyes DC editors. Medical response to terrorism: preparedness and clinical practice. Philadelphia: Lippincott Williams & Wilkins; 2005;p. 26–37
  12. Borron S, Mégarbane B, Baud FJ. Hydroxocobalamin is an effective antidote in severe acute cyanide poisoning in man. Abstract. Int J Toxicol. 2004;23:399–400
  13. Baskin SI, Rockwood GA. Neurotoxicological and behavioral effects of cyanide and its potential therapies. Mil Psychol. 2002;14:159–177
  14. Baskin SI, Brewer TG. Cyanide poisoning. Textbook of military medicine: medical aspects of chemical and biological warfare. Chapter 10. The Virtual Naval Hospital. Available from URL: www.vnh.org/MedAspChemBioWar/chapters/chapter_10.hrmAccessed February 22, 2004
  15. Fortin JL, Ruttiman M, Domanski L, Kowalski JJ. Hydroxocobalamin: treatment for smoke inhalation-associated cyanide poisoning. Meeting the needs of fire victims. JEMS. 2004;29(suppl):18–21
  16. Baud FJ, Borron SW, Megarbane B, Trout H, Lapostolle F, Vicaut E, et al. Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning. Crit Care Med. 2002;30:2044–2050
  17. Benaissa ML, Megarbane B, Borron SW, Baud FJ. Is elevated plasma lactate a useful marker in the evaluation of pure carbon monoxide poisoning?. Intensive Care Med. 2003;29:1372–1375
  18. Agency for Toxic Substances and Disease Registry. US Department of Health and Human ServicesPublic Health Service. Cyanide toxicity. Am Fam Physician. 1993;48:107–114
  19. Koschel MJ. Where there’s smoke, there may be cyanide. Am J Nurs. 2002;102:39–42
  20. Anonymous. Mankato student’s death ruled suicide. CBS Broadcasting Inc., WCCO.com News. March 15, 2006.
  21. Koschel MJ. Management of the cyanide-poisoned patient. J Emerg Med. 2006;32(suppl):S19–S26
  22. American Academy of Clinical ToxicologyEuropean Association of Poisons Centres and Clinical Toxicologists. Position statements: single-dose activated charcoal. Available from URL: http://www.clintox.org/Pos_Statements/Charcoal.htmlAccessed April 2, 2006
  23. Sauer SW, Keim ME. Hydroxocobalamin: improved public health readiness for cyanide disasters. Ann Emerg Med. 2001;37:635–641
  24. Pearce LL, Bominaar EL, Hill BC, Peterson J. Reversal of cyanide inhibition of cytochrome c oxidase by the auxiliary substrate nitric oxide: an endogenous antidote to cyanide poisoning?. J Biol Chem. 2003;278:52139–52145
  25. Baskin SI, Horowitz AM, Nealley EW. The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning. J Clin Pharmacol. 1992;32:368–375
  26. Wananukul W, Kaojarern S. Acute cyanide poisoning: a case report with toxicokinetic study. J Med Assoc Thai. 1992;75:304–309
  27. Hall AH, Kulig KW, Rumack BH. Suspected cyanide poisoning in smoke inhalation: complications of sodium nitrite therapy. J Toxicol Clin Exp. 1989;9:3–9
  28. Jones J, McMullen MJ, Dougherty J. Toxic smoke inhalation: cyanide poisoning in fire victims. Am J Emerg Med. 1987;5:317–321
  29. Becker CE. The role of cyanide in fires. Vet Hum Toxicol. 1985;27:487–490
  30. Borron SW, Barriot P, Imbert M. Hydroxocobalamin for empiric treatment of smoke inhalation-associated cyanide poisoning: results of a prospective study in the prehospital setting. Abstract. Ann Emerg Med. 2005;46:S77
  31. Fortin JL, Waroux S, Ruttimann M, Astaud C, Kowalski JJ. Hydroxocobalamin for poisoning caused by ingestion of potassium cyanide: a case study. Abstract. Clin Toxicol. 2005;43:731
  32. Curry SC, Connor DA, Raschke RA. Effect of the cyanide antidote hydroxocobalamin on commonly ordered serum chemistry studies. Ann Emerg Med. 1994;24:65–67
  33. Gourlain H, Caliez C, Laforge M, Buneaux F, Levillain P. Study of the mechanisms involved in hydroxocobalamin interference with determination of some biochemical parameters. Ann Biol Clin. 1994;52:121–124
  34. Forsyth JC, Mueller PD, Becker CE, Osterloh J, Benowitz NL, Rumack BH, et al. Hydroxocobalamin as a cyanide antidote: safety, efficacy and pharmacokinetics in heavily smoking normal volunteers. J Toxicol Clin Toxicol. 1993;31:277–294
  35. Heyworth-Smith D, Hogan PG. Allergy to hydroxocobalamin, with tolerance of cyanocobalamin. Med J Aust. 2002;177:162–163
  36. Branco-Ferreira M, Clode MH, Pereira-Barbosa MA, Palma-Carlos AG. Anaphylactic reaction to hydroxocobalamin. Allergy. 1997;52:118–119

PII: S0099-1767(06)00270-4

doi: 10.1016/j.jen.2006.05.011

Journal of Emergency Nursing
Volume 32, Issue 4, Supplement , Pages S12-S18 , August 2006

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